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Knaul, F. M., Frenk, J. & Shulman, L. Global Task Force on Expanded Access to Cancer Care and Control in Developing Countries. Closing the Cancer Divide: A Blueprint to Expand Access in Low and Middle Income Countries (Initiative HGE, 2011). In recent times, style icon, beauty mogul, and new mom Rihanna is lensed with her curves in focus for the September 2020 cover story. Other famous faces include Goop mogul Gwyneth Paltrow, the always-stunning Jennifer Aniston, as well as burgeoning supermodel, runway fixture, and J6 brand muse Anok Yai—who was featured in a sexy suiting story months earlier. Hailey Bieber, Demi Lovato, and everyone's favorite modeling duo Bella and Gigi Hadid are also on the list. Of note, when integrating our HM women with independent HM patients from Monterrey, Mexico (GSE75678, n = 53) into a single dataset ( N = 162) we observed that HM series contained 43% LumA tumors, 27% LumB, 16% HER2-enriched and 15% Basal-like (Fig. 1d). Compared to other biospecimen collections including Hispanic patients ( N = 313) from M.D. Anderson Cancer Center (GSE16716, N = 41, Basal-like: 23%), Instituto Nacional de Enfermedades Neoplasicas in Lima, Peru together with the Centro Medico Nacional de Occidente in Guadalajara, Mexico (GSE20271, N = 81, Basal-like: 29%), Hospital San Jose Tec de Monterrey, Mexico (GSE75678, N = 53, Basal-like: 22%) and LACE and Pathways cohorts from USA ( N = 138, Basal-like:27%), our dataset presented a smaller proportion of Basal-like tumors (12% vs. 26% -media proportions of other studies-, Fisher’s exact Benjamini–Hochberg, BH, p = 0.041) (Fig. 1c and Supplementary Data 2) and a significant reduced odds of having this subtype (OR HM dataset vs. Hispanics: 0.522, 95% CI: 0.315–0.866). This differences in subtypes frequency among different Hispanic groups could be partly ascribable to differences in the number of tumors evaluated, batch effects of the collection or to different admixture patterns within these cases.

Whole-exome was captured through Agilent SureSelect ExomePlus bait system (Agilent Technologies, USA) and biotinylated RNA baits 67 process. ~155 Mb baits were target including the standard exome, plus intronic and promoter sequences for known cancer genes, relevant targets identified by cancer genomic studies, TCGA and the Cancer Cell Line Encyclopedia. Exome libraries were sequenced on Illumina GAII or HiSeq 2000 (Illumina, USA) sequencers with 76 base-paired-end reads achieving a mean of 141x. Alignment was performed with the Burrows–Wheeler Alignment tool 68 and standard Picard pipeline to the human genome assembly hg19/GRCh37. Somatic mutation analysis Gonzalez-Perez, A. & Lopez-Bigas, N. Functional impact bias reveals cancer drivers. Nucleic Acids Res. 40, e169 (2012). Ciriello, G. et al. Emerging landscape of oncogenic signatures across human cancers. Nat. Genet. 45, 1127–1133 (2013). Chang, M. T. et al. Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. Nat. Biotechnol. 34, 155–163 (2016). Hyman DM, et al. AKT Inhibition in Solid Tumors With AKT1 Mutations. Journal of Clinical Oncology 35, 2251-2259 (2017).Measurements were performed in a warm room, using measuring tape, with the subject standing on their feet in a standard anatomical position. With both arms extended to the level of the hips, palms facing forward. Measurements were first taken by the same researcher (DFS) and then confirmed by other two.

Vandeput, J.J. and Nelissen, M. (2002) Considerations on Anthropometric Measurements of the Female Breast. Aesthetic Plastic Surgery, 26, 348-355. Kuleshov, M. V. et al. Enrichr: a comprehensive gene set enrichment analysis web server 2016 update. Nucleic Acids Res. 44, W90–W97 (2016). Hannah also pointed out she gets “serious underboob sweat” but said she would be rolling on deodorant under her breasts each day. Of note, when samples are grouped by age, HM patients analyzed did not present statistically significant difference in median TMB values between younger (<45 years old) and older patients, as occurs in tumors from Caucasian and Asian ancestry (TCGA and Japanese dataset) (Fig. 3b) (adjusted p< 0.05). Nor we observed a significant correlation between somatic mutation burden and age in our HM tumor series (Supplementary Fig. 4f). Deciphering mutational signatures Sandra L. Romero-Cordoba, Rosa Rebollar-Vega, Laura Uribe-Figueroa, Luis Alfaro-Ruiz & Alfredo Hidalgo-Miranda

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With the current state of events, celebrating women's bodies is as important as ever. But for BAZAAR, championing curves of every size has always been a priority. As we reflect on some of the best breast moments in the title's history, both understated and overt, it has become clearer with every shot that the feminine anatomy, no matter which way that you look at it, is a work of art.