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Super B-Complex - High Absorption Methylated B Vitamins, Clean Label, Sustained Release - Complete Spectrum of B Vitamins with Folate, Boosted B12 & Vitamin C, 60 Tablets, by Igennus

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In people who are pregnant or breastfeeding or chestfeeding — especially those who follow vegetarian or vegan diets — supplementing with a B-complex vitamin is crucial. Deficiencies in both forms of vitamin B12 can increase your risk of neurological issues and adverse side effects ( 10). If you know you have this genetic mutation or suspect it, then taking supplements that are in their active form can help support optimum methylation. The 7 Nutrients Needed for Methlylation Include:

High doses of supplemental B3 (niacin) may lead to vomiting, high blood sugar levels, skin flushing, and even liver damage ( 34). If pregnant, breast feeding, taking medication, or have a medical condition, please consult your Doctor before use. Unfortunately roughly 40% of the population in the US has a genetic variation affecting the MTHFR gene that can make it difficult for them to produce enough 5-MTHF to run the methylation process efficiently. Some studies suggest that your body may absorb cyanocobalamin slightly better than methylcobalamin. Note that low blood levels of certain B vitamins, including B12, B6, and folate, have been linked to an increased risk of depression, which is why it’s important to rule out nutrient deficiencies if you are experiencing symptoms of depression ( 31, 32). Summary

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B7 (biotin). Biotin is essential for carbohydrate and fat metabolism and regulates gene expression. Yeast, eggs, salmon, cheese, and liver are among the best food sources of biotin ( 6). While B-complex vitamin supplements are not a cure for mental health conditions, they may help improve symptoms of depression or anxiety. Additional studies are needed to measure the absorption and retention of methylcobalamin versus cyanocobalamin in healthy adults. SUMMARY

Methylation requires a specific B vitamin to be present in the body – 5-MTHF (also known as methylfolate).

For example, proton pump inhibitors, which are medications that lower stomach acid, can decrease the absorption of B12, whereas metformin, a popular diabetes drug, can decrease levels of both B12 and folate ( 24, 25). While another essential nutrient, choline, was formerly considered to be a B-complex vitamin and shares some similarities with them, it is in fact neither a vitamin nor a mineral. Summary Additionally, high doses of B6 can cause nerve damage, light sensitivity, and painful skin lesions ( 35). B1 (thiamine). Thiamine plays an essential role in metabolism by helping convert nutrients into energy. The richest food sources include pork, sunflower seeds, and wheat germ ( 1). Advanced – Provides the metabolically active forms of B vitamins including folate as methylfolate, vitamin B12 as methylcobalamin and vitamin B6 as P-5-P

B-complex vitamins are often used to reduce fatigue and boost mood. Some studies suggest that B vitamins can lift your spirits and improve your cognitive performance.

During pregnancy, the demand for B vitamins, particularly B12 and folate, grows. This is because they are needed to support fetal development ( 9). B5 (pantothenic acid). Like other B vitamins, pantothenic acid helps your body obtain energy from food and is also involved in hormone and cholesterol production. Liver, fish, yogurt, and avocado are all good sources ( 4).

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